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    Tuesday, January 8th, 2013
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    Your fertility, meaning your ability to conceive or father a child, may be affected by tamoxifen. Please discuss this issue with your health care provider.

    However, the BCPT study also revealed some serious medical risks, such as an increased risk for endometrial cancer, pulmonary embolism (Blood clot in the lung), stroke, and deep vein thrombosis. Women who took tamoxifen also experienced side effects such as hot flashes, vag-inal dryness, and nausea. Although these side effects were not life-threatening, they were annoying enough that they caused some women to discontinue use of the drug. (For recent news about tamoxifen side-effects, see Related News below.)

    This dosage information may not include all the information needed to use Tamoxifen safely and effectively. See additional information for Tamoxifen.

    For prevention of bre-ast cancer in high risk women, Tamoxifen is usually given in a dose of 20 mg orally, every day for 5 years.

    When Barr initially developed a generic form of tamoxifen, patent litigation ensued. On April 20, 1992, the court found the patent for tamoxifen to be unenforceable, yet while an appeal was pending, the parties reached an agreement. Barr both abandoned its challenge to Zeneca'S tamoxifen patent, and agreed not to manufacture and market its own generic tamoxifen until Zeneca'S patent expires in 2002. In exchange, Zeneca and its former parent (Imperial Chemistry Industries, PLC) agreed to pay Barr $21 million and to supply Barr with Zeneca-manufactured tamoxifen for resale in the United States as a "Generic." This agreement was conditioned upon the United States Court of Appeal for the Federal Circuit ordering the trial court to vacate the finding of patent invalidity, which the trial court subsequently did. The agreement, nonetheless, was privately negotiated without meaningful review or approval by any court.

    The ASCO recommendations provide further guidance for women at high risk due to factors other than suspicious cellular changes (Shown on biopsy). Based on an an-alysis of existing scientific literature, the ASCO guidelines say that women aged 35 or older with at least a 1.66% Risk of getting bre-ast cancer over the next five years should be offered tamoxifen (See below for summarized conclusions to the report). Age itself places a woman at risk, with almost 20 million women over 60 falling into this category.

    Zhan M, Flaws JA, Gallicchio L, Tkaczuk K, Lewis LM, Royak-Schaler R: Profiles of tamoxifen-related side effects by race and smoking status in women with bre-ast cancer. Cancer Detect Prev 2007, 31(5):384-390. PubMed Abstract Publisher Full Text.

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    Dec. 19, 2006 (San Antonio) - Tamoxifen cuts the risk of bre-ast cancer in some women by about a third, a new study confirms, and the benefit persists even after treatment ends.

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    Every Side Effect imaginable, including rapid heart beat.I am going off Arimidex and will take my chances. I am 82 yrs old and can not tolerate 5 yrs of this. I would like to see a study address the outcome of patients over 75yrs with and without Arimidex.

    (Author note: Years back, aromatase inhibitors such as Arimidex and letrozole were much more expensive than Cytadren and much less available, so in the past Cytadren was often used as an aromatase inhibitor. That use is today obsolete.)

    As previously mentioned, those lowered estrogen levels could possibly adversely affect your cholesterol and possibly even your immune function. ANyway Arimidex is recommended for relatively long-term use.

    No im not currently on nor do i plan on being on for a while. However, I have done a fair amount of research and am aware that arimidex is an AI while nolva is a SERM. The 1mg call was off i think during the cycle arimidex actually would be used at around .25Mg? The potential cycle i have developed is structured as follows.

    I started on Arimidex in May 2008 and switched to Anastrazole in late 2010 when I found out about the generic form. I wanted to pay $10 per month rather than the $300+ that I'D been paying for over two and a half years. I still have all the same side effects that I had with Arimidex and no new ones. It'S mainly stiff joints, weight gain and sleeplessness. So far, it'S kept my IBC from recurring, so I'Ll continue to take it.

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    I have been on Tamox for 4 months, but will be having a full hysterectomy next month, followed by Arimidex. My knees hurt, but that is the only SE from Tamox. I am glad you posted postive experiences, because I am hesitant. But I know that pill is my insurance, so I will gladly live with aches and pains anyday over cancer!

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